Forrest CB, Crandall WV, Bailey LC, Zhang P, Joffe MM, Colletti RB  (2014). Effectiveness of anti-TNF for Crohn’s disease: research in a pediatric learning health system. .  Pediatrics 134(1), pg. 37-44.

ImproveCareNow (ICN) is the largest pediatric learning health system in the nation and started as a quality improvement collaborative.  To test the feasibility and validity of using ICN data for clinical research, we evaluated the effectiveness of anti-tumor necrosis factor-α (anti-TNFα) agents in the management of pediatric Crohn disease (CD).

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