Forrest CB, Margolis P, Seid M, Colletti RB (2014). PEDSnet: How A Prototype Pediatric Learning Health System Is Being Expanded Into A National Network.  Health Affairs 33(7), pg. 1171-7.

Except for a few conditions, pediatric disorders are rare diseases.  Because of this, no single institution has enough patients to generate adequate sample sizes to produce generalizable knowledge.

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