Colletti RB, Baldassano RN, Milov DE (2006). Initial dosage of 6-mercaptopurine in pediatric Crohn’s disease: a study of variation in care.  Journal of Pediatric Gastroenterology & Nutrition 43(41), pg. s41.

Variation in care can be due to overuse, underuse or misuse of diagnostic and therapeutic interventions. 6-mercaptopuprine (6MP) and its prodrug azathioprine (AZA) have efficacy in Crohn's disease (CD).  Measurement of thiopurine methyltransferase (TPMT) prior to starting treatment can identify normal genotype or phenotype patients to whom the recommended dose (6MP 1.0-1.5 mg/kg/d) can be administered.

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