Building responsive governance for learning networks

Published April 2022

Porcaro K. Building responsive governance for learning networks. Learn Health Syst. 2021 Aug 5;6(2):e10288. doi: 10.1002/lrh2.10288. PMID: 35434358; PMCID: PMC9006526.

This article describes a strategic governance review of ImproveCareNow (ICN), a learning health network focused on improving clinical outcomes for adolescents with Crohn's disease and ulcerative colitis (IBD). ICN is organized around an "enhanced" patient registry and collaborative community of patients, parents, clinicians, and researchers.

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Overweight and obese status is not associated with disease activity for children and adolescents with newly diagnosed IBD

Published April 2022

Jain A, Bricker J, Kappelman MD, Dotson JL; ImproveCareNow Pediatric IBD Learning Health System. Overweight and obese status is not associated with disease activity for children and adolescents with newly diagnosed IBD. Am J Gastroenterol. 2022 Apr 26. doi: 10.14309/ajg.0000000000001803. Epub ahead of print. PMID: 35470288.

The aim of this study was to evaluate disease-related outcomes in overweight and obese children with CD and UC.

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Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease (PRODUCE): A Series of N-of-1 Diet Trials

Published April 2022

Kaplan HC, Opipari-Arrigan L, Yang J, Schmid CH, Schuler CL, Saeed SA, Braly KL, Chang F, Murphy L, Dodds CM, Nuding M, Liu H, Pilley S, Stone J, Woodward G, Yokois N, Goyal A, Lee D, Yeh AM, Lee P, Gold BD, Molle-Rios Z, Zwiener RJ, Ali S, Chavannes M, Linville T, Patel A, Ayers T, Bassett M, Boyle B, Palomo P, Verstraete S, Dorsey J, Kaplan JL, Steiner SJ, Nguyen K, Burgis J, Suskind DL; ImproveCareNow Pediatric IBD Learning Health System. Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease (PRODUCE): A Series of N-of-1 Diet Trials. Am J Gastroenterol. 2022 Apr 20. doi: 10.14309/ajg.0000000000001800. Epub ahead of print. PMID: 35442220.

Evidence about Specific Carbohydrate Diet (SCD) for inflammatory bowel disease (IBD) is limited. We conducted 54 single-subject, double-crossover N-of-1 trials comparing SCD to a modified SCD (MSCD) and comparing each to the participant's baseline, usual diet (UD).

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Web-Based Mindfulness-Based Interventions for Well-being: Randomized Comparative Effectiveness Trial

Published September 2022

Sylvia LG, Lunn MR, Obedin-Maliver J, McBurney RN, Nowell WB, Nosheny RL, Mularski RA, Long MD, Merkel PA, Pletcher MJ, Tovey RE, Scalchunes C, Sutphen R, Martin AS, Horn EJ, O'Boyle M, Pitch L, Seid M, Redline S, Greenebaum S, George N, French NJ, Faria CM, Puvanich N, Rabideau DJ, Selvaggi CA, Yu C, Faraone SV, Venkatachalam S, McCall D, Terry SF, Deckersbach T, Nierenberg AA. Web-Based Mindfulness-Based Interventions for Well-being: Randomized Comparative Effectiveness Trial. J Med Internet Res 2022

Mindfulness can improve overall well-being by training individuals to focus on the present moment without judging their thoughts. However, it is unknown how much mindfulness practice and training are necessary to improve well-being.

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