The PRODUCE Study is now officially enrolling eligible participants. Four ImproveCareNow centers, including Seattle Children’s Hospital, Stanford Children's Health, Nemours Children's Health System - Wilmington, and Children’s Mercy are actively recruiting participants. The remaining seven centers should be recruiting participants by May.

PRODUCE is a research study that will use a series of N-of-1 trials to understand the effectiveness of the specific carbohydrate diet (SCD) in reducing symptoms and inflammation in patients with Crohn’s disease and ulcerative colitis (also known as Inflammatory Bowel Disease or IBD), as compared to a modified SCD and usual diet.


There are currently over 25,000 patients with IBD and their families receiving care at ImproveCareNow centers, and, for many, understanding the role of diet therapy in the management of IBD is a high priority. To date, there is insufficient evidence on the effectiveness of the SCD compared to other diets in reducing IBD symptoms and inflammation. Over the course of this project, a series of N-of-1 trials will be used to examine how the SCD affects individual patients.

Study participants will use the Eureka mobile app to track information about their IBD symptoms and to support their progress through their individual N-of-1 trial. After completing an N-of-1 study, the Eureka platform will present personalized results to each patient-clinician team using easy-to-understand graphics.

At the culmination of the study, the research team aims to bring together the results of 100 individual N-of-1 studies to look at the effectiveness of the SCD in the pediatric IBD population.


More information about the PRODUCE Study

For more information about Research in ImproveCareNow, visit our Research Opportunities page >>

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