Rachael L. Fleurence, PhD, MSc, is the former Senior Advisor to Dr. Francis Collins at the National Institutes of Health, leading a national initiative to eliminate Hepatitis C in the U.S. She was also an advisor to the National Institute of Biomedical Imaging and Bioengineering (NIBIB), focusing on Artificial Intelligence and Machine Learning. Previously, she served as a senior health policy advisor in the Biden-Harris White House and as Senior Advisor to the NIH Director. She played a key role in the federal COVID-19 response, leading the “Say Yes! Covid Test” program and serving on White House pandemic policy groups. She previously led the National Evaluation System for health Technology Coordinating Center (NESTcc) and PCORnet at PCORI and spent several years in the private sector in Health Economics and Outcomes Research consultancy space. Dr. Fleurence has received multiple NIH Director’s Awards, the HHS Secretary’s Award for Distinguished Service, and the National Champion for Global Hepatitis Elimination award. She previously led the National Evaluation System for health Technology Coordinating Center (NESTcc) and PCORnet at PCORI. She co-led the ISPOR Task Force on EHR data for Health Technology Assessment, is a member of the ISPOR Working Group on Generative AI and an associate editor for the journal Value in Health. She is a member of the Board of CTTI, the Clinical Trials Transformation Initiative and ICN, the ImproveCareNow network. She holds degrees from Cambridge University, ESSEC-Paris, and the University of York in the UK.