Learning health systems as facilitators of precision medicine

Published February 17, 2017 

Ramsey L, Mizuno T, Vinks A, Margolis PA. Learning health systems as facilitators of precision medicine.  Clinical Pharmacology & Therapeutics 2017; 101(3): 359-367

The concept of the learning health system offers promise to facilitate personalized medicine. In children, serious illness is uncommon, so generating and applying new knowledge therefore requires networks of institutions. To illustrate the concept of the Learning Health System, we describe the example of the ImproveCareNow Network. We then use a network case study to illustrate how the concept of precision medicine can be achieved through a Learning Health System in a real-world clinical environment.

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Race differences in initial presentation, early treatment, and 1-year outcomes of pediatric Crohn's disease: results from the ImproveCareNow network

Published May 2017

Dotson JL, Cho M, Bricker J, Kappelman MD, Chisolm DJ, Tomer G, Crandall WV . Race differences in initial presentation, early treatment, and 1-year outcomes of pediatric Crohn's disease: results from the ImproveCareNow network.  Inflamm Bowel Dis 2017;23(5): 767-774

Racially disparate care has been shown to contribute to suboptimal health care outcomes for minorities. Using the ImproveCareNow network, we investigated differences in management and outcomes of pediatric patients with Crohn's disease at diagnosis and 1-year post-diagnosis.

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Perianal Crohn's disease in a large multicenter pediatric collaborative

Published May 5, 2017

Adler J, Dong S, Eder S, Dombkowski K . Perianal Crohn's disease in a large multicenter pediatric collaborative. J Pediatr Gastroenterol Nutr 2017;64(5): e117-e124

Although perianal complications of Crohn disease (CD) are commonly encountered in clinical practice, the epidemiology of perianal CD among populations of children is poorly understood. We sought to characterize the prevalence of perianal disease in a large and diverse population of pediatric patients with CD.

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Quality items required for running a paediatric Inflammatory Bowel Disease Centre: an ECCO paper

Published August 1, 2017

Turner D, Carle, A, Steiner S, Margolis PA, Colletti R, Russell RB, Levine A, Kolho K, Ruemmele F, ICN Network . Quality items required for running a paediatric Inflammatory Bowel Disease Centre: an ECCO paper.  Journal of Crohn's and Colitis 2017;11(8): 981-987 

The importance of a holistic approach with a comprehensive multidisciplinary team, including nutritional and psychosocial support, is becoming well recognised as a key contributor to optimal care in paediatric inflammatory bowel disease [IBD]. The Paediatric committee of ECCO [P-ECCO] aimed to determine important components that would contribute to quality of care in a paediatric IBD centre.

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